Publications
2025
Schrott S., Gerle C., Bibinger S., Bertgen L., Marino G., Schwenkert S., Rathberger R., Herrmann JM., Osman C.(2025) Mrx6 binds the Lon protease Pim1 N-terminal domain to confer selective substrate specificity and regulate mtDNA copy number, bioRxiv
2024
Bertram N., Izawa T., Thoma F., Wagener F., Schwenkert S., Osman C., Neupert W., Mokranjac D. (2024) Delayed protein translocation protects mitochondria against toxic CAT-tailed proteins, bioRxiv
Roussou R., Metzler D., Padovani F., Thoma F., Schwarz R., Shraiman B, Schmoller KM. & Osman C. (2024) Real-time assessment of mitochondrial DNA heteroplasmy dynamics at the single-cell level, The EMBO Journal, Vol 43: 5340 - 5359
Rossi M., Hausmann AE., Alcami P., Moest M., Roussou R., Van Belleghem S., Wright DS., Kuo C., Lozano-Urrego D., Maulana A., Melo-Flórez L., Rueda-Muñoz G., McMahon S., Linares M., Osman C., McMillan O., Pardo-Diaz C., Salazar C. & Merrill RM. (2024) Adaptive introgression of a visual preference gene, Science, Vol 383, Issue 6689: 1368-1373
2023
Schrott S. & Osman C. (2023) Two mitochondrial HMG-box proteins, Cim1 and Abf2, antagonistically regulate mtDNA copy number in Saccharomyces cerevisiae, Nucleic Acids Research, gkad849
Seel A., Padovani F., Mayer M., Finster A., Bureik D., Thoma F., Osman C., Klecker T. & Schmoller KM (2023) Regulation with cell size ensures mitochondrial DNA homeostasis during cell growth, Nature Structural and Molecular Biology, Vol 30, Issue 10: 1549-1560
2022
Weihan L., Maekiniemi A., Sato H., Osman C. & Robert H. Singer (2022) An improved imaging system that corrects MS2-induced RNA destabilization, Nature Methods, Vol 19, Issue 12:1558-1562
Sharma N. and Osman C. (2022) Yme2, a putative RNA Recognition motif and AAA+ domain containing protein, genetically interacts with the mitochondrial protein export machinery, Biol. Chem., Vol 403, Issue 8-9:807-817
Bunk D., Moriasy J., Thoma F., Jakubke C., Osman C. & Hörl D. (2022) YeastMate: Neural network-assisted segmentation of mating and budding events in S. cerevisiae, Bioinformatics, Vol 38, Issue 9:2667-2669
2021
Seel A., Padovani F., Finster A., Mayer M, Bureik D., Osman C., Klecker T. & Schmoller KM. (2021) Regulation with cell size ensures mitochondrial DNA homeostasis during cell growth, bioRxiv
Jakubke C.*, Roussou R.*, Maiser A., Schug C., Thoma F., Bunk D., Hörl D., Leonhardt H., Walter P., Klecker T. & Osman C. (2021) Cristae-dependent quality control of the mitochondrial genome. Science Advances, Vol 7, Issue 36
Rackles E., Witting M., Forné I., Zhang X., Zacherl J., Schrott S., Fischer C., Ewbank J.J., Osman C., Imhof A. & Rolland S.G. (2021) Reduced peroxisomal import triggers peroxisomal retrograde signaling. Cell Reports, Volume 34, Issue 3
2019
Aretz, I., Jakubke, C. & Osman, C. (2019) Power to the daughters - mitochondrial and mtDNA transmission during cell division. Biol. Chem.
Göke A., Schrott S., Mizrak A., Belyy V., Osman C. & Walter P. (2019) Mrx6 regulates mitochondrial DNA copy number in S. cerevisiae by engaging the evolutionarily conserved Lon protease Pim1. Mol. Biol. Cell.
2018
Aretz I., Jakubke C. & Osman C. (2018) Wie Zellen den Erhalt des mitochondrialen Genoms sicherstellen. BIOspektrum Volume 24, Issue 6, pp 586–589
2016
Aaltonen M.J., Friedman J.R., Osman C. Salin B., diRago J.P., Nunnari J., Langer T. & Tatsuta T. (2016)
MICOS and phospholipid transfer by UPS2-Mdm35 organize membrane lipid synthesis in mitochondria. J. Cell Biol., 10.1083/jcb.201602007
2015
Osman C., Noriega T.R., Okreglak V., Fung J.C. & Walter P. (2015) Integrity of the yeast mitochondrial genome, but not its distribution and inheritance, relies on mitochondrial fission and fusion. Proc. Natl. Acad. Sci. U. S. A. 112: E947–56
2014
Van Anken E., Pincus D, Coyle S., Aragón T., Osman C., Lari F., Gómez Puerta S., Korennykh A. V. & Walter P. (2014) Specificity in endoplasmic reticulum-stress signaling in yeast entails a step-wise engagement of HAC1 mRNA to clusters of the stress sensor Ire1. Elife 3:e05031
2013
Murley A., Lackner L.L.*, Osman C.*, West M., Voeltz G.K., Walter P. & Nunnari J. (2013) ER-associated mitochondrial division links the distribution of mitochondria and mitochondrial DNA in yeast. Elife 2: e00422, *contributed equally
2011
Kornmann B., Osman C. & Walter P. (2011) The conserved GTPase Gem1 regulates endoplasmic reticulum–mitochondria connections. Proc. Natl. Acad. Sci. U. S. A. 108: 14151–14156
Osman C., Voelker D.R. & Langer T. (2011) Making heads or tails of phospholipids in mitochondria. J. Cell Biol. 192: 7–16
2010
Osman C., Haag M., Wieland F.T., Brügger B. & Langer T. (2010) A mitochondrial phosphatase required for cardiolipin biosynthesis: the PGP phosphatase Gep4. EMBO J. 29: 1976–87
Potting C., Wilmes C., Engmann T., Osman C. & Langer T. (2010) Regulation of mitochondrial phospholipids by Ups1/PRELI-like proteins depends on proteolysis and Mdm35. EMBO J. 29: 2888–98
2009
Osman C., Haag M., Potting C., Rodenfels J., Dip P.V., Wieland F.T., Brügger B., Westermann B. & Langer T. (2009) The genetic interactome of prohibitins: coordinated control of cardiolipin and phosphatidylethanolamine by conserved regulators in mitochondria. J. Cell Biol. 184: 583–96
Osman C., Merkwirth C. & Langer T. (2009) Prohibitins and the functional compartmentalization of mitochondrial membranes. J. Cell Sci. 122: 3823–30
Haag M., Osman C., Langer T., Wieland F.T. & Brügger B. (2009) Quantification of cardiolipin molecular species by targeted product ion analysis. Chem. Phys. Lipids 160:
2007
Osman C., Wilmes C., Tatsuta T. & Langer T. (2007) Prohibitions Interact Genetically with Atp23 , a Novel Processing Peptidase and Chaperone for the F 1 F O -ATP Synthase. Mol. Biol. Cell 18: 627–635