Cell and Development Biology

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Schrott S. & Osman C. (2023) Two mitochondrial HMG-box proteins, Cim1 and Abf2, antagonistically regulate mtDNA copy number in Saccharomyces cerevisiae, Nucleic Acids Research, gkad849

Seel A., Padovani F., Mayer M., Finster A., Bureik D., Thoma F., Osman C., Klecker T. & Schmoller KM (2023) Regulation with cell size ensures mitochondrial DNA homeostasis during cell growth, Nature Structural and Molecular Biology, Vol 30, Issue 10: 1549-1560


Weihan L., Maekiniemi A., Sato H., Osman C. & Robert H. Singer (2022) An improved imaging system that corrects MS2-induced RNA destabilization, Nature Methods, Vol 19, Issue 12:1558-1562

Sharma N. and Osman C. (2022) Yme2, a putative RNA Recognition motif and AAA+ domain containing protein, genetically interacts with the mitochondrial protein export machinery, Biol. Chem., Vol 403, Issue 8-9:807-817

Bunk D., Moriasy J., Thoma F., Jakubke C., Osman C. & Hörl D. (2022) YeastMate: Neural network-assisted segmentation of mating and budding events in S. cerevisiae, Bioinformatics, Vol 38, Issue 9:2667-2669


Seel A., Padovani F., Finster A., Mayer M, Bureik D., Osman C., Klecker T. & Schmoller KM. (2021) Regulation with cell size ensures mitochondrial DNA homeostasis during cell growth, bioRxiv

Jakubke C.*, Roussou R.*, Maiser A., Schug C., Thoma F., Bunk D., Hörl D., Leonhardt H., Walter P., Klecker T. & Osman C. (2021) Cristae-dependent quality control of the mitochondrial genome. Science Advances, Vol 7, Issue 36

Rackles E., Witting M., Forné I., Zhang X., Zacherl J., Schrott S., Fischer C., Ewbank J.J., Osman C., Imhof A. & Rolland S.G. (2021) Reduced peroxisomal import triggers peroxisomal retrograde signaling. Cell Reports, Volume 34, Issue 3


Aretz, I., Jakubke, C. & Osman, C. (2019) Power to the daughters - mitochondrial and mtDNA transmission during cell division. Biol. Chem.

Göke A., Schrott S., Mizrak A., Belyy V., Osman C. & Walter P. (2019) Mrx6 regulates mitochondrial DNA copy number in S. cerevisiae by engaging the evolutionarily conserved Lon protease Pim1. Mol. Biol. Cell.


Aretz I., Jakubke C. & Osman C. (2018) Wie Zellen den Erhalt des mitochondrialen Genoms sicherstellen. BIOspektrum Volume 24, Issue 6, pp 586–589



Aaltonen M.J., Friedman J.R., Osman C. Salin B., diRago J.P., Nunnari J., Langer T. & Tatsuta T. (2016)
MICOS and phospholipid transfer by UPS2-Mdm35 organize membrane lipid synthesis in mitochondria. J. Cell Biol., 10.1083/jcb.201602007


Osman C., Noriega T.R., Okreglak V., Fung J.C. & Walter P. (2015) Integrity of the yeast mitochondrial genome, but not its distribution and inheritance, relies on mitochondrial fission and fusion. Proc. Natl. Acad. Sci. U. S. A. 112: E947–56


Van Anken E., Pincus D, Coyle S., Aragón T., Osman C., Lari F., Gómez Puerta S., Korennykh A. V. & Walter P. (2014) Specificity in endoplasmic reticulum-stress signaling in yeast entails a step-wise engagement of HAC1 mRNA to clusters of the stress sensor Ire1. Elife 3:e05031


Murley A., Lackner L.L.*, Osman C.*, West M., Voeltz G.K., Walter P. & Nunnari J. (2013) ER-associated mitochondrial division links the distribution of mitochondria and mitochondrial DNA in yeast. Elife 2: e00422, *contributed equally


Kornmann B., Osman C. & Walter P. (2011) The conserved GTPase Gem1 regulates endoplasmic reticulum–mitochondria connections. Proc. Natl. Acad. Sci. U. S. A. 108: 14151–14156

Osman C., Voelker D.R. & Langer T. (2011) Making heads or tails of phospholipids in mitochondria. J. Cell Biol. 192: 7–16


Osman C., Haag M., Wieland F.T., Brügger B. & Langer T. (2010) A mitochondrial phosphatase required for cardiolipin biosynthesis: the PGP phosphatase Gep4. EMBO J. 29: 1976–87

Potting C., Wilmes C., Engmann T., Osman C. & Langer T. (2010) Regulation of mitochondrial phospholipids by Ups1/PRELI-like proteins depends on proteolysis and Mdm35. EMBO J. 29: 2888–98


Osman C., Haag M., Potting C., Rodenfels J., Dip P.V., Wieland F.T., Brügger B., Westermann B. & Langer T. (2009) The genetic interactome of prohibitins: coordinated control of cardiolipin and phosphatidylethanolamine by conserved regulators in mitochondria. J. Cell Biol. 184: 583–96

Osman C., Merkwirth C. & Langer T. (2009) Prohibitins and the functional compartmentalization of mitochondrial membranes. J. Cell Sci. 122: 3823–30

Haag M., Osman C., Langer T., Wieland F.T. & Brügger B. (2009) Quantification of cardiolipin molecular species by targeted product ion analysis. Chem. Phys. Lipids 160:


Osman C., Wilmes C., Tatsuta T. & Langer T. (2007) Prohibitions Interact Genetically with Atp23 , a Novel Processing Peptidase and Chaperone for the F 1 F O -ATP Synthase. Mol. Biol. Cell 18: 627–635